Mazzarri was questioned in his press conference about some of the options for this weeks emergency defensive pairing, given the absences of both Rolando and Samuel. Mazzarri responded well to questions of whether it is possible to use Cambiasso in central defence, which was previously done in the match against Napoli last year. The Inter coach was not opposed to this option, stating; “We have tried several solutions, including a back four. I’ll see how we can make changes during the game as well, but Cambiasso is so adaptable that he can play in multiple different roles.
Source: fcinternews.it

let andreolli have a chance
I trust Cambiasso as a central defender, but I trust no one to replace him in midfield.
So no.