Stefano Pioli is set to start with a four-man defence against his former side Lazio.
Danilo D’Ambrosio, Miranda, Jeison Murillo and Cristian Ansaldi are set to line-up in front of Samir Handanović.
Marcelo Brozović and Geoffrey Kondogbia will sit in front of the back four, whilst Antonio Candreva, Éver Banega and Ivan Perišić will support Mauro Icardi in attack.
The coach has reportedly paid particular attention to how he intends to stop Lucas Biglia dictating the play in midfield and will therefore opt for a 4-2-3-1 formation.
Source: La Gazzetta dello Sport