Juventus will be without Juan Cuadrado and Alex Sandro for the Derby d’Italia and Federico Bernardeschi could make a surprise start.
Inter face the Bianconeri in the Derby d’Italia on Sunday night as they look to win in this fixture for the first time since 2016.
A win would see the Nerazzurri go seven points clear of the reigning champions, who will have some notable absences.
As Corriere dello Sport explains Matthijs de Light, Cuadrado and Alex Sandro will all be out after testing positive for coronavirus.
In addition Paulo Dybala is injured and the newspaper believes there could be a surprise start for Bernardeschi.
The former Fiorentina man has struggled since moving to Turin but could be given the chance to prove himself on Sunday night.
Pirlo is expected to set up in a 4-4-2 with veteran Giorgio Chiellini starting in the centre of defence, with Aaron Ramsey preferred to Weston McKennie in midfield.
Probable Juventus XI: Szczesny; Danilo, Bonucci, Chiellini, Frabotta; Bernardeschi, Bentancur, Rabiot, Ramsey; Morata, Ronaldo
