Inter Milan will be desperate to shine in a high-profile clash when they lock horns with Atletico Madrid on Wednesday night.

According to Tuttosport via FCInterNews, the San Siro giants are poised to address their long-standing problems against top teams.

Despite having AC Milan on the ropes in Sunday’s Derby della Madonnina, Inter slumped to a gut-wrenching 1-0 defeat.

Indeed, Cristian Chivu failed on his touchline debut in this iconic fixture, even though the Nerazzurri performed far better than their arch-rivals.

Inter Milan Eager to Defy ‘Big-Match’ Taboo vs Atletico Madrid

Cristian Chivu Inter Milan
MILAN, ITALY – OCTOBER 04: FC Internazionale coach Cristian Chivu looks on before the Serie A match between FC Internazionale and US Cremonese at Giuseppe Meazza Stadium on October 04, 2025 in Milan, Italy. (Photo by Marco Luzzani/Getty Images)

Inter faced Milan without several first-team stars, including Henrikh Mkhitaryan and Denzel Dumfries.

However, they outplayed the Rossoneri, making 20 shots whilst generating a telling 1.92 xG, only to lose in the end.

Furthermore, it was Inter’s third ‘high-profile’ defeat in Serie A this season after losing to Juventus and Napoli.

Therefore, Chivu will be keen to end this ominous trend tomorrow.

In addition to meeting Atletico Madrid, Inter will take on Arsenal, Liverpool, and Borussia Dortmund in the Champions League.

Defying their underwhelming results against top teams will, therefore, be crucial to their hopes of securing automatic last-16 qualification.