Inter vs Cremonese will see Cristian Chivu make changes as Marcus Thuram is sidelined with a muscular problem, meaning Ange-Yoan Bonny is expected to partner Lautaro Martinez in attack.
Thuram has been ever-present for Inter this season.
His injury against Slavia Prague leaves Chivu without one of his most important players.
Bonny, however, has already shown promise, scoring on his debut.
Francesco Pio Esposito could also be used from the bench, after the youngster got his first league goal in the win over Cagliari.
Inter Vs Cremonese Changes Expected In Defence And Midfield As Bonny Comes In For Thuram
According to the Corriere dello Sport, Chivu will rotate in other areas too.
Manuel Akanji is due to return in defence, with Alessandro Bastoni possibly rested for Carlos Augusto.
In midfield, Nicolò Barella and Henrikh Mkhitaryan are set to feature in the starting eleven alongside Hakan Calhanoglu.
The Nerazzurri will look to maintain momentum after back-to-back wins against Sassuolo and Cagliari.
Facing Cremonese, who remain unbeaten this season, will be another test of Inter’s squad depth without Thuram.